DOUBLE MARKER TEST Double Marker Test is a type of test that in mainly given to pregnant women to determine any chromosomal malformation in the foetus. This test also plays a vital role in the detection of any kind of neurological conditions in the foetus, such as down’s syndrome or Edward’s Syndrome. In fact it is detection of pre-birth conditions of the fetus and is usually done after 8 weeks of pregnancy up to 14 weeks. This test detects any kind of chromosomal abnormalities that might occur after the conception occurs. This is not completely unusual as it occurs in every 700 births. The probability of having a baby with chromosomal imbalance or Down’s syndrome is likely for elderly pregnant women. It is advisable that all pregnant women should go through this test so that she is sure that the baby is completely normal. PROCEDURE: An 12 weeks ultrasound is done to measure the NT( nucal trasulency ). The blood sample is then collected ( preferably within 24 hours) for the double marker test.The Double Marker Test looks for two markers namely Free Beta hCG (human chorionic gonadotrophin) and PAPP – A (Pregnancy associated plasma protein A).  Free Beta hCG is a glycoprotein hormone produced by the placenta during pregnancy. It’s high level is indicative to a higher risk of Trisomy 18 and Down’s syndrome. PAPP – A is a vital plasma protein. A low level of plasma protein is indicative of the risk of down syndrome. The NT measurement is also taken into account to report the test. The test readings are signified in terms of screen positive, high risk and screen negative. to be continued.....dr nandini shete...gynecologist.